|
a,
Analysis of amphetamine-stimulated rotations in animals grafted with neurons
derived from wild-type (WT) (n = 10) or Nurr1 ES cells (n = 15)
and sham controls (n = 18). b−e, Non-pharmacological evaluation of the
animals grafted with either WT or Nurr1 ES cells (mean s.e.m.). b, Nine weeks
after grafting and one week after the last injection of amphetamine,
spontaneous turning behaviour was evaluated for 5 min. c, The
results in the adjusting step test are expressed as a percentage of the
lesioned side relative to the number of steps with the non-lesioned paw. d,
In the paw-reaching test, the number of pellets eaten with the lesioned paw
were normalized by the total number of pellets eaten during the 7-day test
period. e, In the cylinder test, the use of each limb was measured
when rearing and landing. The percentage of use of the lesioned-side limb
relative to the total number of landings after rearing is expressed,
Asterisk, P < 0.05; double asterisk, P < 0.001, compared
with sham group.
|