特別演講(二)

P-6
Materials Technology in Medicine
Idea Brewing and Research Design
林峰輝 Feng-Huei Lin
Division of Medical Engineering Research, NHRI, Chu-Nan, Taiwan
Institute of Biomedical Engineering, College of Medicine, NTU, Taipei, Taiwan

As a material researcher, I am very happy to have an opportunity to give a talk in the Annual Meeting of the Society. I have no idea how to organize my talk before give the abstract. I had several experiences on technology transferring those were finally commercialized. However, most of the technology transferring cases can not be among the high tech or advanced tech, that are not so scientific or too loose to give a talk in the annual meeting. After deeply think for several days, I decided to organize a talk related with how a material researcher to collect research idea and what role I play in the biomaterial development. Some of my important research work in the recent 10 years will be incorporated into the talk; and the topic of the talk is ironed as “Materials Technology in Medicine – Idea Brewing and Research Design”.

Over the last several years, my lab have developed some of bioreactors based on the needed of bone tissue engineering and cartilage tissue engineering. New materials have been prepared and designed for the tissue replacement, cell tracking, and cancer treatment.

Double-chamber bioreactor, that could co-culture two kinds of cells in one device to stimulate each other for tissue growth without additional growth factors, has been developed for the skin tissue engineering where dermal fibroblast and keratinocyte were seeded on to culture together for skin equivalent tissue to be growth in vitro.

The tricopolymer, that contained three major components of extacellular matrix (ECM), hyaluroinc acid, chondroitin sulfate and collagen, has been prepared as a scaffold for osteochondral graft tissue engineering. The material is to simulate the ECM of articular cartilage that to “cheat” cell something like at home to proliferate in proper way, to differentiate toward desire pathway, and eventually to grow up into full-blown tissue.

Biodegradable magnetic nano-sized DP-bioglass was prepared to generate heat upto 43aC-46aC in the tumor site or cancer area to kill the cancer cell and keep normal cell alive. The surface of the nano-particle was modified with biomarker for targeting purpose to deliver the nano-particle to the tumor site.
The mentioned design and materials would be integrated into the talk to give a picture what I have done, what troubled me and what help I need in the future. I hope the talk let you understand “Engineer” always do the best to help push medical study going on for human being health.