Nanotechnology shows very strong synergy with the development of advanced imaging technologies that enabled improved clinical disease management. We have successfully developed several novel platforms in novel imaging probe synthesis that covered MRI, CT and photoacoustics imaging. Superparamagnetic nanoparticles were synthesized in aqueous phase with amine surface function group to reveal hepatoma lesions in vivo. Porous iron oxide nanorods with polymer shell were engineered to present a combined MR imaging tracking and controlled drug release function by disease local microenvironment. We further synthesized octahedron iron oxide nanocrystal with integrated alpha iron as the core and a polymeric shell to tag anti-cancer drug and molecular targeting function. The particles were able to present synchronized targeted hyperthermia and chemotherapy as well as MR molecular imaging of tumor bearing mice. Iron platinum alloy particles with antibody conjugation were developed to achieve CT/MRI dual modal molecular imaging contrast of Her2 in mice. For the multiplex Molecular photoacoustic imaging, we engineered gold nanorods of different aspect ratio that enabled them to be differentially excited by a wavelength tunable laser system thus to generate multiplexed molecular photoacoustic imaging in vitro and in vivo. By increase in laser energy and mode, the targeted probes could relay the photonic energy into localized heat that effectively kill the cancer cells. Through innovative design of nanoprobes, integration of molecular imaging and therapeutics will be come a future
trend in advanced disease management strategy that would revolutionize clinical medicine.