專題討論1:腦瘤的放射手術治療

程 序 表

S1-5
腦下垂體腫瘤之放射手術治療
Radiosurgery in pituitary tumor treatment
曾漢民
臺大醫院神經外科

  Surgery remains as the treatment of choice in the management of pituitary tumor except some prolactinoma. However, total adenomectomy is not achievable in every pituitary tumor surgery. Conventional radiotherapy had been used as one of the adjuvant therapy. Although it is effective to control the lesion but the coverage field is large and the treatment length is 5 weeks or longer.
  Stereotactic radiosurgery was used to replace the role of conventional radiotherapy. Single fraction (Stereotactic radiosurgery ) or low multifractions ( Stereotactic radiotherapy) provide precise coverage of the tumor with low dose radiation dose to the surrounding normal brain tissue. For nonfunctional tumor the tumor size control rate is high but it took several years. For the growth hormone secreting tumor the endocrinological normalization also takes several years with a successful rate around 60 %. As the majority of prolactinoma is responsive to dopamine receptor agonist well radiosurgery is seldom used in prolactinoma therapy. The result of radiosurgery to ACTH secreting pituitary tumor was reported to be 80% or more and as fast as 2 years. In order to protect the visual acuity at least 2 mm distance between lesion and optic apparatus is required in radiosurgery. Hypopituitarism occurs in some cases.
  Conclusion: stereotactic radiosurgery was applied to treat the pituitary tumor with good tumor size and endocrinological control. Both visual acuity and pituitary endocrinological function preservation can be achieved with proper patient selection.