While engineered devices have long been used for clinical purposes, developments in science and technology continue to bring new opportunities and challenges.? Due to increasingly close and complex interactions between the body and engineered devices or materials, future progress hinges on better understanding of the body, particularly various physical and chemical signals from tissues and organs and the responses of tissues and cells to artificial materials and stimulations.? Examples will be presented to illustrate several emerging areas.? First, research on cellular responses to mechanical properties of the environment has impacted conceptually on applications from tissue regeneration to cancer treatment.? Second, better knowledge in cardiac functions and blood susceptibility has led to innovative cardiac assist devices based on fluid dynamics and native tissues.? Third, mathematical analysis of brain neural signals has laid the groundwork for brain-computer interfaces and associated robotic devices to assist patients of neuromuscular deficits.
　　 雖然工程裝置的臨床應用行之已久，科技發展繼續帶來新的機會與挑戰。基於這些新裝置或材料與人體間的密切複雜互動，未來發展必需依賴對人體的深入瞭解，特別是來自組織器官的各種物理與化學訊號，及組織細胞對人為材料與刺激的反應。演講中將用案例說明幾項發展。第一，關於細胞對環境力學性質反應的研究已對組織再生及腫瘤治療方面帶來觀念上的影響。第二，基於心臟機能與血液損傷的瞭解，當前研究已開始運用流體力學及人體組織製作新式心臟輔助裝置。第三，對腦部神經訊號的數學分析已為人腦電腦間的界面立下基礎，以用來操控彌補神經肌肉功能障礙的機器人。