The most common intraocular tumor in adults is metastatic tumor. It has been reported that about 10% of patients who died of metastatic cancers had intraocular metastasis according to the autopsy reports. As long-term survival from systemic primary malignancy continues to increase, the ophthalmologist will be confronted with a growing incidence of intraocular metastatic disease requiring prompt recognition and appropriate diagnostic and therapeutic management.
　　The most frequent intraocular site for metastasis is choroid; iris and ciliary body are less common. The most common site of primary tumor is breast in female and lung in male. Most of the metastatic tumors are carcinoma, and few are sarcoma or melanoma. Bilateral ocular involvement has been reported in 20-25% of cases, and multifocal deposits are frequently seen. Most patients with ocular metastases also have concurrent CNS metastases.
　　Patients with choroidal metastatic tumor in the posterior pole commonly complain of loss of vision. Indirect fundoscopy may reveal one or more yellow-white subretinal mass, and pigment clumps at the level of retinal pigmented epithelium are often seen. Exudative retinal detachment may also accompany. Ultrasonography is helpful in differential diagnosis. B-scan shows an echogenic choroidal mass with an ill-defined outline, and A-scan demonstrates moderate to high internal reflectivity.
　　Chemotherapy is often used as a frontline therapy for intraocular metastatic tumor. Radiotherapy may also be used for local tumor control. The diagnosis of tumor metastasis usually implies a poor systemic prognosis, because widespread dissemination of the primary tumor has usually occurred.