教育演講4:影像醫學之進展
Recent advace in medical imaging

程 序 表

E4-4
整合型磁振正子造影在兒科疾病的應用
彭信逢
臺灣大學醫學院放射線科

  Patients with neuroblastoma have to receive regular follow-up examinations including F18-DOPA PET and MR imaging to monitor recurrence of tumors. The conventional CT-PET is about twice the radiation dosage of CT. It is reasonable to replace CT-PET by MR-PET with decrease of ionizing radiation and let patients receive MR and PET examinations simultaneously. F18-DOPA is manufactured by NTUH and already on the market. Ten cooperative neuroblastoma patients were recruited to receive F18-DOPA MR-PET examinations immediately after regular CT-PET examinations without use of additional isotopes. The residual proton density from F18, contrast-enhanced MR images were collected and correlated with the regression or progression in the follow-up images of neuroblastoma. F18-DOPA MR-PET of 12 patients detected 41 neuroblastoma lesions but 2 of the bone marrow lesions were not shown on F18-DOPA PET-CT. No additional lesions were only detected by F18-DOPA PET-CT images. The max SUV contrast ratios of 39 neuroblastoma lesions were not significantly different between F18-DOPA MR-PET and F18-DOPA PET-CT images. The results of the study show promising application of hybrid F18-DOPA MR-PET to evaluate the treatment efficacy and prognosis of children with neuroblastoma. In addition, hybrid PET-MR with optimal metabolic and anatomic evaluation provides excellent image fusion and registration in situ and helps treatment planning of intractable seizure.