There are a lot of emerging technologies in the field of prenatal diagnosis in recent 10 years such as chromosome microarray, preimplantation genetic diagnosis/screening, and non-invasive prenatal testing. Moreover, newer technologies such as whole exome sequencing or even whole genome sequencing had gradually been put into clinical practice in selected conditions. These advanced tests had revolutionarily reshaped the landscape of the whole field, consequently changed the clinical practice. The speaker will give a talk to discuss the indications, limitations, as well as how to counsel in certain difficult scenarios.