近二十年來，生物製劑包括標靶治療及免疫療法蓬勃發展，運用於各領域，尤其是癌症的治療。比起傳統的化學療法，這些生物製劑具有針對性，理論上引起較少的副作用。然而，身體其他組織如眼睛因為也有這些標靶的表現，所以也可能受到波及。一般而言，生物製劑所引起的眼科副作用常被忽視，但可能會影響生活品質，嚴重也會造成視力受損。在此，我將討論這些生物製劑造成眼表層的副作用其可能的致病機轉、臨床表現及治療。使用生物製劑的醫生和眼科醫師都必須對此有所了解，才能早期診斷予以立即及適當的治療。
　　There has been an increase in the use of biologicals including targeted therapy and immunotherapy, particularly in oncology practice. over the past 20 years. Although these agents are thought to be more specific and less toxic than traditional cytotoxic chemotherapy, they are associated with a variety of toxicities, including ocular side effects due to their specific targeting of activities in the eye. Here, we will discuss the proposed pathogenesis, monitoring guidelines, and management recommendations for the adverse events of biologicals on the ocular surface and adnexa. Collaboration between oncologists and ophthalmologists is important to diagnose and treat these side effects promptly.