施行細胞治療技術醫師訓練課程(二)

cell2-16
An introduction on pluripotent stem cell and their applications
郭紘志教授
中央研究院細胞與個體生物學研究所

  Pluripotent stem cells (PSCs) can be derived from fertilized blastocysts (embryonic stem cells, ESCs), be reprogrammed from somatic cells by enucleated oocytes (nuclear transferred ESCs, ntESCs) or by defined transcription factors (induced pluripotent stem cells, iPSCs). They are extremely important as the mechanisms underlying cellular differentiation and self-renewal can be studied. Also, patient-specific iPSCs and ntESCs are ideal for cell-based disease modeling and drug testing. Importantly, the person-specific pluripotent stem cells can be used as an isogenic cell resources for autologous cell transplantation. Thus, provide an excellent opportunity for treating many human diseases, which has no cure so far. In this lecture, I will briefly review the development of stem cell technologies and discuss their potential for various application, including iPSC-based cellular therapy.